Vaccine-induced autoimmune hepatitis


 

To the Editor:

We have read with interest the recent cases suggesting the possibility of vaccine-induced immune-mediated hepatitis with Pfizer-BioNTech and Moderna mRNA-1273 vaccines for the SARS-CoV-2 virus. (1,  2,  3,  4,  5,  6,  7)

However, as the cohort of vaccinated individuals against COVID-19 increases, the previously reported cases could not exclude a coincidental development of autoimmune hepatitis, which has an incidence of 3/100,000 population per year.[8] 

Our case demonstrates conclusive evidence of vaccine-induced immune-mediated hepatitis with a rapid onset of liver injury after the first Moderna dose, which on re-exposure led to acute severe autoimmune hepatitis.


Source:

https://www.journal-of-hepatology.eu/article/S0168-8278(21)02093-6/fulltext#sectitle0035